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The Cancer Genome Atlas
- Description
The Cancer Genome Atlas (TCGA), a landmark cancer genomics program, molecularly characterized over 20,000 primary cancer and matched normal samples spanning 33 cancer types. This joint effort between NCI and the National Human Genome Research Institute began in 2006, bringing together researchers from diverse disciplines and multiple institutions. Over the next dozen years, TCGA generated over 2.5...
- Subject
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CancerGenome, HumanGenomics
- Access Rights
- Free to All
- Local Expert
- Nyasha Chambwe
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Immunoglobulin intraclonal diversification in Chronic Lymphocytic Leukemia tumor cells
Internal Dataset- Authors
- Davide BagnaraCatherine TangJennifer BrownSiddha Kasar15 more author(s)...
- Description
We used a DNA sequencing approach that achieves considerable depth and minimizes artefacts and amplification bias to identify IGHV-IGHD-IGHJ subclones in patients with prolonged temporal follow-up. Our findings extend previous studies, revealing intraclonal IGHV-IGHD-IGHJ diversification in almost all CLL clones. Also, they indicate that some subclones with additional IGHV-IGHD-IGHJ mutations can become...
- Subject
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CancerGenome, HumanGenomics
- Access Rights
- Free to All
- Local Expert
- Nicholas Chiorazzi
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Size distribution of function-based human gene sets and the split-merge model
Internal Dataset- Authors
- Wentian LiOscar FontanelliPedro Miramontes
- Description
The sizes of paralogues—gene families produced by ancestral duplication—are known to follow a power-law distribution. We examine the size distribution of gene sets or gene families where genes are grouped by a similar function or share a common property. The size distribution of Human Gene Nomenclature Committee (HGNC) gene sets deviate from the power-law, and can be fitted much better by a beta rank...
- Subject
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Genome, HumanGenomics
- Access Rights
- Free to All
- Local Expert
- Wentian Li
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- Genome, Human 3
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